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Manny "Pacman" Pacquiao defeated defending champion Miguel Cotto on Saturday in the 12th round to claim the WBO welterweight title.
The victory extended Pacquiao's record number of weight division titles to seven, according to news services.
Cotto took a one-pound advantage over Filipino Pacquiao into the superfight in Las Vegas.
Puerto Rico's Cotto weighed in at 145 pounds in front a 5,000 strong crowd at the MGM Grand Arena, with Pacquiao tipping the scales at 144 pounds. He looked relaxed and smiled as he stripped to his boxer shorts, while Cotto looked more intense.
Video: Pacquaio focuses on 7th title
Saturday's match was Pacquiao's first fight since a stunning knockout of Britain's Ricky Hatton sixth months ago at the same venue.
Pacquiao, who has won 49 fights, lost three and drawn two, is being lined up for a money spinning fight with American Floyd Mayweather, but first must get past the determined Cotto, who has held a world title every year since 2004.
Pacquiao was rated as favorite by Las Vegas oddsmakers, but Cotto had just one defeat in 35 fights with 27 knockouts going into the Saturday bout.